Necrotizing myopathy is a newly defined form of idiopathic inflammatory myopathy, or myositis. Patients with necrotizing myopathy have muscle biopsies that show much less inflammation in the muscle tissue than polymyositis patients, but they have …

Jun 14, 2024 · Necrotizing myopathy is a rare disorder of muscles with no known etiology in more than 50% of cases. Recognition of risk factors, identification of associated autoantibodies including SRP and HMGCR, timely muscle biopsy, and early aggressive immunotherapy are associated with improved outcomes.

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Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement.

Immune-Mediated Necrotizing Myopathy (IMNM), also referred to as Necrotizing Autoimmune Myopathy (NAM), one of the Inflammatory Myopathies, is a rare, thought to be complement-mediated muscle disease.

The hallmark feature of people with immune-mediated necrotizing myopathy (IMNM) is the presence of proximal muscle weakness. Most affected people experience only weakness, and the presence of other (extra-muscular) symptoms, such as skin or lung manifestations, suggests that they may have another type of IIM rather than IMNM.

Immune-mediated necrotizing myopathy (IMNM) is a distinct subgroup of inflammatory myopathy typically characterized by myofiber necrosis with minimal inflammatory infiltrates on muscle biopsy, highly elevated creatine kinase levels, and infrequent extra-muscular involvement.

Immune-mediated necrotizing myopathy (IMNM) is one of the idiopathic inflammatory myopathies (IIMs), a group of muscle diseases that involves inflammation of the muscles or associated tissues. The IIMs are sometimes referred to as simply “myositis.”

•Immune mediated necrotizing myopathies (Hoogendijk) with anti-SRP+, anti-HMGCoA Reductase+ (post-statines), or paraneoplastic

See the diagnostic criteria for a necrotizing myopathy diagnosis, including the features and findings from an EMG and muscle biopsy.