Several elements of how the Monster Manual is organized put a low-magic setting easily within reach for Dungeon Masters willing to put in the work. The most obvious is the entirety of Appendix A: Animals,

The new Dungeons & Dragons Monster Manual is here, but is it a necessary purpose for those playing since 2014?

Monster Manual will feature many monsters that return from previous editions, but a new addition could rival the game's most formidable foe.