The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Just as the San Francisco 49ers won’t miss seeing Aaron Donald lining up for the Los Angeles Rams on Sunday, Sean McVay won’t ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

Alvin Kamara surpassed Christian McCaffrey in career touchdowns scored, ranking sixth-best among active players. Klint Kubiak ...

San Francisco 49ers star running back Christian McCaffrey could be out for six weeks or more due to his calf soreness and ...

Justin Jefferson, who hauled in a wild 97-yard touchdown catch in the first half, left the game early with a quad injury.

49ers coach Kyle Shanahan said the timeline for running back Christian McCaffrey’s return is unknown.

A disaster scenario has hit fantasy football managers who spent an early first-round pick on San Francisco 49ers star ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...