Mayer’s home run is the lone positive for Boston so far in this game. The Sox trail 8-1 in the sixth inning. The Yankees pounded starter Walker Buehler for seven runs (five earned), seven hits, two homers and two walks in the first two innings.

Boston made its first run at the Yankees in the sixth when Warren lost the strike zone after five solid innings. He gave up a leadoff triple by Jarren Duran and then issued three walks around Wilyer Abreu's sacrifice fly, and manager Aaron Boone had seen enough.

The Boston Red Sox will meet the New York Yankees in the first of a three-game weekend series on Friday. New York (38-23) leads the American League East, while Boston (30-34) is fourth in the division.