BALTIMORE - The skidding Baltimore Orioles lost to the San Francisco Giants, 5-3, Wednesday night at Camden Yards. Mike Yastrzemski homered on the game's first pitch, Michael Conforto also hit a solo shot for the Giants, who took the first two games in the series.

The San Francisco Giants (74-78) and Baltimore Orioles (84-68) clash Thursday afternoon to finish off a 3-game series. First pitch from Oriole Park at Camden Yards is slated for 1:05 p.m. ET (MLB Network).

Anthony Santander hit a two-run home run in the bottom of the ninth Thursday, giving the Orioles a much-needed 5-3 win.