Cancer Research11d
The Mode of Action and Clinical Outcomes of Sacituzumab Govitecan in Solid Tumors
Free SN-38 can subsequently enter the tumor microenvironment and kill adjacent tumor cells with or without Trop-2 expression (bystander effect). SN-38 induces DNA breakage and inhibits nucleic acid ...
Cancer Research11d
OBI-992, a Novel TROP2-Targeted Antibody–Drug Conjugate, Demonstrates Antitumor Activity in Multiple Cancer Models
After transduction, pooled stable cell lines were selected using 2 µg/mL of puromycin. Human TROP2 expression in stable cells was confirmed using flow cytometry. An MC38/hTROP2 syngeneic tumor model ...
Protective role of mitochondrial protein Mitofusin 2 in cellular health revealed
A European research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating Ch ...
Nature12d
Metabolic selection of glycosylation defects in human cells
Unnatural intermediates are used to challenge a specific pathway, and cell surface expression ... 2-epimerase, in the absence of structural information. Characterization of another cell line ...
pharmaphorum3d
AZ and Daiichi's TROP2 ADC shows promise in first-line lung cancer
As a first-line therapy, DS-1062/Keytruda had an ORR ... Most EGFR-mutated NSCLCs show some level of HER3 expression, but for now there are no HER3 directed therapies approved for NSCLC or any ...
Frontiers12d
Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington’s disease
3.2 Differential analysis of miRNA expression in human cell models between HTT-Q23 and HTT-Q74 cell lines In order to evaluate altered miRNA expression in SH-SY5Y cells stably expressing wild-type and ...