eLife1d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
chromatographyonline1d
Advancing Gene Therapy: Enzyme Selection For Effective RNA Oligonucleotide Mapping
New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), ...
eLife10d
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...
Frontiers10d
Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis
In addition to strong differential gene expression, comprising metabolic as well as ... This procedure comprises a so-called 2D-analysis preprocessing step where a bivariate Gaussian mixture model was ...
BMJ18d
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
ki.se Objectives: A gene–environment interaction between HLA-DR shared epitope ... cells from smokers has led to the suggestion that citrullination induced by smoking might be the first step in the ...
Frontiers5d
Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
Blocking steps and antibody incubations were performed in Odyssey ... supplied with Odyssey CLx Imaging System (LI-COR Biosciences, United States). 2.10 Gene expression analysis by quantitative PCR To ...
New York Post11d
Serial squatter allegedly exploits dozens of Malibu homeowners — and problem could get worse due to LA wildfires
A Malibu real estate agent warned California homeowners about the need to protect themselves after a serial squatter reportedly targeted the beachfront community for years, a problem she said ...
New work proposes a unifying model of Alzheimer's disease: Large-scale alterations to gene expression
In a novel theory, scientists at Arizona State University's Biodesign Institute propose a unifying explanation for the ...
Precision gene therapy for liver disorders increases number of correctly repaired cells
Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...
Us Weekly9d
The Rookie’s Mekia Cox Teases Oscar Hutchinson’s Return, Harper’s Next Steps After Serial Killer Attack (Exclusive)
When episode 5, which aired on Tuesday, February 4, picked up, Harper learned that she was in fact attacked by a serial killer who previously infected his victims with diseases. “She immediately ...