differentiation therapy of hematopoietic malignancies, and stem cell expansion for therapeutic benefits. By profiling gene expression in HSCs, we identified an RNA-binding protein called Musashi-2 ...

Every second, an adult generates around five million new blood cells to replace aging or dying ones, making the blood system a highly regenerative organ.

The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells. MSK investigators have used ... separated nuclear body that suppresses myeloid leukemic ...

Hematopoietic (blood ... and the SMA iPS cells showed reduced capacity to form mature motoneurons in culture when compared with those derived from normal iPS cells. The second case involves ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

Hematopoietic stem cells (HSCs) are immature progenitor cells ... proliferative capacity and to block differentiation. By studying differentiation and self-renewal mechanisms in normal stem cells and ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model ... the intestinal microbiome is required to maintain normal ...

These changes impair normal gene regulation ... the regulation of gene activity, and the differentiation of hematopoietic ...