When both are mutated, it eventually leads to a differentiation block downstream of CSF3R ... while repressing the granulo-monocytic transcription factor C/EBPα. This results in dominance of GATA1 ...

The derivatives for any functions like polynomial, power, exponential, logarithmic and circular functions can be easily found by knowing the derivative for their base function. For example, the ...

005). 4 Notably, AUTX-703 was well-tolerated across all doses. These findings also showed that AUTX-703 selectively degraded KAT2A/B, inducing monocytic differentiation and inhibiting cell ...

GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further differentiate into monocytes/macrophages and ...

are able to transform hematopoietic cells and skew the hematopoietic differentiation program towards the monocytic/macrophage lineage. We also report that the patient associated with the BCR-RET f ...