When both are mutated, it eventually leads to a differentiation block downstream of CSF3R ... while repressing the granulo-monocytic transcription factor C/EBPα. This results in dominance of GATA1 ...

THP-1 = Human acute monocytic leukemia cell line. Disclosure: Research in Kris Chadee's laboratory is supported by grants from the Crohn's and Colitis Foundation of Canada, the Canadian Institute ...

Ephs are associated with many different malignancies and, as in other settings, adopt varied and often conflicting roles. Ephs may behave in a similar manner to oncogenes or tumor suppressors [52 ...

We discovered that regulatory element accessibility precedes gene expression during PGC development, suggesting that changes in chromatin accessibility may prime PGC lineage commitment prior to ...

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...

cluster of differentiation (CD) 4 and forkhead box protein 3 (FoxP3)], infiltrating antitumor CD8 T cells (Ki-67 and CD8), and regulatory tumor-associated macrophages (TAMs; CD68 and PD-L1), and ...

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Drug Delivery, Disposition & Dynamics, Monash Institute of ...

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