Molecular dynamics is a method that uses Newton’s equations of motion to computationally simulate the time evolution of a set of interacting atoms. Such techniques are dependent on a description ...
Genetics and Molecular Biology considera contribuições que apresentem os resultados de pesquisas originais nas áreas de genética, evolução e disciplinas científicas relacionadas. Genetics and ...
HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Proteostasis is maintain by a proteostasis network. Proteostasis has multiple levels of regulation. A great number of molecular chaperones are present in the cytosol, assisting on the appropriate ...
Figure 7. Orchestrating proinsulin proteostasis in β-cells: Molecular Chaperones, oxidoreductases, and the UPR. (1) PERK ablation, leading to Erp72 upregulation, may impair proinsulin degradation or ...
It's part of a broad initiative across Mass General and its sister hospitals to incorporate professional observers — known as chaperones — into routine medical care. The Mass General Brigham ...
Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, F-33607 Pessac, France ...
Molecular Cancer Research publishes articles featuring novel, basic cancer research discoveries that prioritize broad molecular and cellular processes. Areas of emphasis include cell cycle and ...
Molecular chaperones are vital proteins that maintain protein homeostasis by assisting in protein folding, activation, degradation, and stress protection. Among them, heat-shock protein 90 (Hsp90) ...
Molecular Cancer Therapeutics publishes articles on the discovery and preclinical development of novel therapeutic agents for oncology, preclinical studies of approved therapeutics, mechanisms of drug ...
The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB ...
This folding is assisted by chaperones (which are themselves also proteins). Cells adjust the number of chaperones so that there are enough to cope with the burden of unfolded proteins. However, in ...
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