eLife13d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
eLife7d
Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules
This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...
EMBO Press6h
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...
The EMBO Journal12d
Sertm2 is a conserved micropeptide that promotes GDNF-mediated motor neuron subtype specification
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. An evolutionarily conserved micropeptide, ...
Frontiers27d
Protein-induced modulation of chloroplast membrane morphology
Transient expression of outer envelope proteins or protein domains such as CHUP1-TM–GFP, outer envelope protein of 7 kDa ... reveal the different morphologies of plant mitochondria. Images are single ...
BMJ15d
Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
1 A hallmark of RA pathology is synovitis, causing the synovium to thicken and form a pannus that invades cartilage and bone, driven by pathogenic transformation and proliferation of fibroblasts with ...
Frontiers21d
Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling
Organoids are stem-cell derived tissue structures mimicking specific structural ... the toxic effects on the retina when administering chloroquine and gentamicin, an anti-malaria drug and an ...
C&EN25d
Design, Synthesis, and Characterization of pH-Resettable Photoswitches Mimicking the GFP Fluorophore Structure
Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy ...