Recent advances in molecular antibody biology and structural protein engineering enabled the modification ... including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...

Recombinant antibodies are invented antibodies formed by using recombinant DNA technology. While traditional monoclonal ...

Under transient and stable transfection conditions, the SV40 intron can obtain the highest transgene expression level among five introns, which can also obtain high-level of recombinant protein ...

are commonly employed for antibody purification procedures [19]. Although protein A may bind to the Fab region of antibodies, the interacting amino acids might be located in the framework region (FR) ...

Chronic liver damage in BMP-9-deficient mice or in mice adenovirally overexpressing the selective BMP-9 antagonist activin-like kinase 1-Fc resulted in reduced deposition ... Bone morphogenetic ...

Immunotherapy. 2012;4(11):1167-1179. Up to half the patients on anti-TNF-α therapies have inadequate responses. Substantial inter- and even intra-individual variations in the pharmacokinetics of ...

Understanding where and how an antibody binds to its target protein is important for understanding how the ... high affinity and specificity to an antibody antigen binding fragment (Fab), crystal ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

Many vaccines work by introducing a protein to the body that resembles ... It's an exciting step forward in fine-tuning antibody and vaccine-based strategies against HIV and other diseases." ...