New findings on the power of enzymes could reshape biochemistry
Using a series of more than 1,000 X-ray snapshots of the shapeshifting of enzymes in action, researchers at Stanford ...
The American Journal of Managed Care1d
TROPION-Breast01: Datopotamab Deruxtecan Improves Progression-Free Survival
Aditya Bardia, MD, MPH, FASCO, medical oncologist, UCLA Health, discusses findings from the TROPION-Breast01 study on ...
Scientists propose CDK2 enzyme as new target for cancer therapy
An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic ...
The American Journal of Managed Care1d
TALAPRO-2 Overall Survival Data Suggest New Standard of Care in mCRPC, Regardless of Genomic Status
Positve overall survival data could lead to a label expansion for Pfizer's combination to treat metastatic ...
Harvard Medical School1d
New Imaging Technique Illuminates Bacterial Gene Activity
Researchers have created a novel imaging-technology combination that can capture gene activity in individual bacteria in ...
EurekAlert!1d
Protective role of mitochondrial protein Mitofusin 2 in cellular health revealed
A European research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating Ch ...
A newly discovered biomarker can predict cancer aggressiveness
Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD ...
BioSpace17d
Vincerx Pharma, Inc. and Oqory, Inc. Highlight Promising Data for Oqory’s TROP2 Antibody Drug Conjugate, OQY-3258
OQY-3258, also known as ESG401, is an anti-TROP2 ADC currently under evaluation in three clinical trials: A Phase 3 study as a first-line treatment in patients with ... PFS of 7.4 (3.7-9.2) months.
Medscape18d
Trop-2 Protein Overexpression is an Independent Marker for Predicting Disease Recurrence in Endometrioid Endometrial Carcinoma
This study corroborates previous reports on the importance of Trop-2 expression in human tumors to stratify biologically aggressive disease variants. Importantly, because Trop-2 overexpression may ...