Results of two phase 2 studies suggest efgartigimod could be a potential treatment for myositis and Sjögren disease in ...

From drug trials to mechanistic insights, EULAR 2025 delivers wide-ranging data that may inform tomorrow’s standards in ...

Myopathy can be divided into three categories: myalgias, myositis and rhabdomyolysis. Myalgias are described as a soreness, tenderness or weakness of muscles, either at rest or brought on by exertion.

Statin-induced myopathy is a well-known adverse effect. Recently, short-term administration of statins has been shown to decrease cardiorespiratory fitness through inducing mitochondrial damage. [5] ...

Recent findings regarding interferon and Janus kinase inhibition may hold clues to improving outcomes in patients with complex myositis, according to a presenter at the Biologic Therapies Summit ...

"We have identified a group of patients with a necrotizing myopathy and a novel anti-200/100 autoantibody specificity," said Dr. Andrew Mammen, M.D., Ph.D., and lead author of the study.

Most myositis trials have few non-White participants; however, diversity is improving. Trials lack sites in South/Central America, Africa, and Southeast Asia, highlighting geographic disparities.

Diagnosis of Sporadic Inclusion Body Myositis The clinical diagnosis of sIBM is confirmed by muscle biopsy, and is aided by electromyography (EMG) and determination of serum muscle enzyme levels ...

The fact that creatine kinase levels are not significantly elevated in the statin group might point towards irisin being an early marker of statin-induced myopathy.

Anti-HMGCR antibodies showed highest predictive value for a myositis diagnosis, followed by anti-MDA5, anti-Jo-1, and anti-TIF1-γ, an analysis of 1068 people with positive myositis antibodies showed.

Statin rechallenge with a different member of the statin class has been studied. [12] The proportion developing myopathy on introduction of other statins among patients with known simvastatin ...

Maria Del Grande; Lisa Christopher-Stine Disclosures Int J Clin Rheumatol. 2012;7 (3):243-246.