Neuropathy is a debilitating type of pain caused by injury or damage to nerves. Although many factors lead to neuropathy, the imbalance between damaging free radicals and protective antioxidants ...

Various measures of abnormal left atrial (LA) structure or function (LA myopathy) are associated with a higher risk of ischemic stroke and dementia, independent of atrial fibrillation. However, ...

Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle ...

Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune inflammatory disorders characterised by symmetrical skeletal muscle weakness and accelerated fatigue also in the early ...

The disorder can also affect the nervous system, leading to peripheral neuropathy — damage or dysfunction of the peripheral nerves, which are nerves external to the brain and spinal cord.

A number of proteins regulating this process are mutated in human diseases. We focus on centronuclear myopathy due to mutations in the large GTPase dynamin 2 (DNM2), the first protein shown to ...

Figure 1: Pedigree and genotypic analysis of a DRM family. Figure 2: Transverse cryostat sections of the muscle from a DRM patient (III8 on pedigree). Figure 3: Cytoplasmic aggregates are formed ...

Purpose: Taxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and ...