When both are mutated, it eventually leads to a differentiation block downstream of CSF3R ... while repressing the granulo-monocytic transcription factor C/EBPα. This results in dominance of GATA1 ...

Ephs are associated with many different malignancies and, as in other settings, adopt varied and often conflicting roles. Ephs may behave in a similar manner to oncogenes or tumor suppressors [52 ...

The derivatives for any functions like polynomial, power, exponential, logarithmic and circular functions can be easily found by knowing the derivative for their base function. For example, the ...

We discovered that regulatory element accessibility precedes gene expression during PGC development, suggesting that changes in chromatin accessibility may prime PGC lineage commitment prior to ...

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...

Research in my group focusses on the mechanism of action of mycolactone, the lipid-like exotoxin of the Buruli ulcer infectious agent, Mycobacterium ulcerans. Mycolactone has many unusual and ...

Clinical and Radiographic Outcomes of Four Different Treatment Strategies in Patients With Early Rheumatoid Arthritis (the Best Study): A Randomized, Controlled Trialfrom Arthritis & Rheumatism ...

ABSTRACT Introduction: The treatment of elderly multiple myeloma (MM) patients with autologous stem cell transplantation (ASCT) is a controversial procedure. Most clinical trials evaluating the safety ...

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Drug Delivery, Disposition & Dynamics, Monash Institute of ...

Department of Biomolecular Sciences, Faculty of Biochemistry, Weizmann Institute of Science, Rehovot 7610001, Israel ...