Proteostasis is maintain by a proteostasis network. Proteostasis has multiple levels of regulation. A great number of molecular chaperones are present in the cytosol, assisting on the appropriate ...

Figure 7. Orchestrating proinsulin proteostasis in β-cells: Molecular Chaperones, oxidoreductases, and the UPR. (1) PERK ablation, leading to Erp72 upregulation, may impair proinsulin degradation or ...

The partnership aims to leverage Magnet’s discovery platform for detecting molecular glues capable of inducing protein proximity and co-operativity. Credit: shisu_ka/Shutterstock. Magnet Biomedicine ...

A growing number of hospitals are utilizing medical chaperones as part of their efforts to bolster safety, according to a Feb. 24 report from NPR affiliate WBUR. Medical chaperones are ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. No ...

It's part of a broad initiative across Mass General and its sister hospitals to incorporate professional observers — known as chaperones — into routine medical care. The Mass General Brigham ...

Outer membrane proteins (OMPs) are crucial for the survival of bacteria. The two chaperones 17-kilodalton protein (Skp) and survival factor A (SurA) play key roles in OMP maturation by keeping ...

Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, F-33607 Pessac, France ...

Molecular Cancer Research publishes articles featuring novel, basic cancer research discoveries that prioritize broad molecular and cellular processes. Areas of emphasis include cell cycle and ...

Molecular chaperones are vital proteins that maintain protein homeostasis by assisting in protein folding, activation, degradation, and stress protection. Among them, heat-shock protein 90 (Hsp90) ...