HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Proteostasis is maintain by a proteostasis network. Proteostasis has multiple levels of regulation. A great number of molecular chaperones are present in the cytosol, assisting on the appropriate ...
Figure 7. Orchestrating proinsulin proteostasis in β-cells: Molecular Chaperones, oxidoreductases, and the UPR. (1) PERK ablation, leading to Erp72 upregulation, may impair proinsulin degradation or ...
The partnership aims to leverage Magnet’s discovery platform for detecting molecular glues capable of inducing protein proximity and co-operativity. Credit: shisu_ka/Shutterstock. Magnet Biomedicine ...
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