Mouse models for hemophilia A are commonly generated by factor VIII (FVIII) knockout, however, these mice rapidly develop anti-FVIII antibodies during repetitive FVIII administration. To overcome this ...

This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

That the mice reached adulthood at all was possible ... and that “it’s really not a small feat to make those 20-knockout stem cells while maintaining the developmental potential in a way ...

Many foods are often advertised for their antioxidant properties. Antioxidants counteract what are known as reactive oxygen ...

Scientists have discovered that the peptide hormone adrenomedullin plays a pivotal role in obesity-related type 2 diabetes, ...

It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.