One-step creation of Cre-loxP organisms: Precise control and modification of gene expression
Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...
eLife1d
Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability
The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...
Science Daily1d
Starting points for the control of protein synthesis
The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...
New toolbox aids in characterizing internal ribosomal entry sites in cells
Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active ...
eLife12d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
News-Medical.Net on MSN4d
A versatile toolbox sets gold standard for characterizing IRES activity in cells
Only recently has the ribosome - one of the oldest molecular machines in evolutionary terms - been recognized as an active regulator of gene expression at the level of protein biosynthesis.
Medical Xpress25d
Identification of gene in malarial parasite brings researchers one step closer to an effective live vaccine
It is precisely this that current vaccines do not offer, but Heussler's team has taken a new approach and identified a gene in the malaria parasite that brings research one step closer to ...