Numbers after gene ... T cells showed dim or absent p53, a finding consistent with reduced expression in clonal T cells (Figure 1C). To understand the kinetics of clonal emergence, we performed ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Figure 1 Age-associated changes in memory T cell composition with aging. Memory T cells are a heterogeneous and dynamic population that undergoes several kinds of transitions, including loss or gains ...

The latter can activate B cells, which in turn produce the nAbs against the capsid and transgene product. After prolonged or inadequate stimulation ... expression kinetics, are also more prone than ...

Ever since the cell was ... greatly affect gene expression. Cellular atlases are unlocking the mysteries of the human body But some of this functional diversity in the observed t-types might ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying a specific gene improves the ability of immune cells to combat cancer for ...

Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...

Monoclonal T cells from both patients had detectable CAR transgene expression and ... baseline and 3 and 6 months after cilta-cel infusion. A monoclonal T-cell receptor (TCR) β-chain (TCRβ ...

How do bacteria—harmless ones living in our bodies, or those that cause disease—organize their activities? A new study, ...

Researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

A breakthrough study sheds new light on how brain cells relay critical information ... connects local synaptic activity to the broader gene expression changes necessary for learning and memory ...