Fortunately, the cell has intrinsic quality control mechanisms to maintain ... Under homeostatic conditions, ER-resident protein chaperone glucose regulated protein 78 (GRP78) interacts with these ER ...

Immunohistochemistry (IHC) was performed to detect GRP78, ATF-6 and TXNIP expression in vivo ... rats and stimulated with TGF-β1 to establish a KOA cell model and investigate whether CHR can alleviate ...

TUNEL Assay Kits were used to measure apoptotic cells in livers ... (A) Western blot analysis of p-IRE1α, IRE1α, GRP78, CHOP, RIPK1 and GAPDH in liver tissue. (B) Experiment schema. (C) ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

Ever since the cell was recognized as the basic unit of life almost 200 years ago, biologists have been on a quest to characterize and classify the myriads of distinct cell types that make up each ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ...

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to ...

The following is a summary of “Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer,” published in ...

How do bacteria—harmless ones living in our bodies, or those that cause disease—organize their activities? A new study, ...

All cells, including neurons, require proteins to function properly. These are produced through a process known as gene expression, in which the relevant information is copied from a gene into ...