Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.

And the reason we're not doing that is because siRNAs antisense oligonucleotides, indeed antibodies can antagonize ... we used a mouse model which enables you to engraft or essentially place ...

Many modern drugs are based on antibodies. These proteins very specifically identify a certain structure on the surface of ...

Insect miRNAs can be transferred to their host plants upon feeding. This study shows that a conserved insect microRNA plays a ...

R-708-5p is a stress-regulated microRNA and a potential biomarker for the differential diagnosis of human mood disorders.

Time-lapse confocal live imaging of 8-week K14:H2B-GFP murine MG explant in which all ... The researchers used a mouse model system for most of their analyses because the meibomian glands of ...

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

The PVDF membrane was then blocked with 5% skim milk powder at room temperature for 2 h, washed with PBS for 3 min, and incubated overnight at room temperature with the following rabbit anti-mouse ...