Vision restored: Retinal therapy research marks first successful induction of long-term neural regeneration
Vision is one of the most crucial human senses, yet more than 300 million people worldwide are at risk of vision loss due to ...
EMBO Press1d
Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II
Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...
bjo.bmj26d
Longitudinal change of peripapillary vessel density and retinal nerve fibre layer thickness in normal tension and primary angle closure glaucoma
gmail.com; Professor Clement C Tham; clemtham{at}cuhk.edu.hk Purpose To compare the rates of peripapillary vessel density (pVD) loss and retinal nerve fibre layer (RNFL) thinning in normal tension ...
The EMBO Journal27d
AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo
To address this, we previously used transgenic mouse models to show that neurogenesis can be stimulated in the adult mammalian retina by driving regeneration programs that other species activate ...
bjo.bmj28d
Profile of retinal nerve fibre layer symmetry in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases study
Background To examine the normative profile and determinants of retinal nerve fibre layer (RNFL) symmetry in a non-glaucoma, multiethnic Asian population. Methods Chinese, Malay and Indian adults aged ...
eLife1mon
Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors
Cells were counted in four independent assays (n = 83 and 85 cells for GFP-dHR and GFP-RH, respectively). Figure 6. R-loops are dynamic in the mouse ... to their expression levels. Figure 8. A ...
Frontiers1y
Epitranscriptomic investigation of myopia-associated RNA editing in the retina
In contrast, RNA editing enriched in controls was mostly involved in post-embryonic eye morphogenesis. Our results demonstrate altered A-to-I RNA editing associated with myopia in an experimental ...
Frontiers3y
Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy
Molecular analysis showed that retinal progenitor ... While the gene expression and scRNA-seq validated that photoreceptor cells were differentiated, not all organoids were able to develop an uniform ...
eLife6y
Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization
We discovered that ablation of the TGFβ receptor, TGFBR2, in retinal microglia of adult mice induced abnormal microglial numbers, distribution, morphology, and activation status, and promoted a ...