DNA polymerase (DNAP) is a type of enzyme that is responsible for forming new copies of DNA, in the form of nucleic acid molecules. Nucleic acids are polymers, which are large molecules made up of ...

1) would probably lead to early embryonal or ... the potential to either inactivate the polymerase, or to form polymerase–DNA crosslinks. In the case of cancer treatment, an important strategy ...

1 Denaturation: Double-stranded DNA separates into single ... 6 A combination of highly processive thermostable DNA polymerase and a high-fidelity polymerase with 3′-5′ exonuclease activity helps ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA clearance following damage, driven by the exonuclease activity of the mtDNA ...

Direct chemical synthesis has been adapted to make oligonucleotides of remarkable length, including an 800 nucleotide green ...

That discovery led to the invention of the polymerase chain reaction, or PCR (as in the PCR tests we took during the pandemic), which enables scientists to select specific DNA fragments and then ...

Scientists use short oligonucleotides as primers for polymerase chain reaction and next-generation sequencing, in DNA microarrays and fluorescence in situ hybridization, and in antisense therapies. (1 ...

where the enzyme DNA polymerase zips along the single strands starting at the primer to replicate the DNA. The cycle repeats and copies of the original DNA accumulate exponentially. Like any ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine ...