Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

In all cases, the flap sequence significantly enhanced GFP transduction mediated by the HIV vector. Figure 1: The HIV-1 central DNA flap enhances gene transduction of primary neural cells.

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in ... Feb. 4, 2025 — Researchers have ...

Mar. 19, 2025 — The cells that make up the walls of the finest of all lymphatic vessels have a lobate, oak leaf-like shape that makes them particularly resilient to changes in fluid volume.

Immunotherapy has emerged as one of the major options for cancer treatment in the past decade. With the successful application of immune checkpoint inhibitors and the introduction of immune regulatory ...

For further details, see the online supplementary methods section. Cell viability was measured in three independent replicates 72 hours after drug treatment using MTS assays according to the ...