Successful CAR-T cell therapy for end-stage multiple myeloma using advanced cellular product performed in Hong Kong
A clinical team has spearheaded the use of CAR-T cell therapy for blood cancers. The researchers recently treated the first ...
AZoLifeSciences on MSN3d
How B Cells Know When to Mutate—and When to Chill
Study reveals B cells suppress mutations during rapid division, enhancing immune response and offering critical insights for ...
Mirage News4d
HKUMed Pioneers CAR-T Therapy for Myeloma in HK
The research team, led by Professors Kwong Yok-lam (front right) and Eric Tse Wai-choi (front left), successfully utilises ...
CAR T-cell therapy tricks cancer cells with decoy, increases treatment efficiency in B-cell acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most ...
eLife12d
Thrifty wide-context models of B cell receptor somatic hypermutation
They also show that models learned from nonsynonymous mutations and from out-of-frame sequences are different, prompting new questions about germinal center function. Strengths of the study include an ...
BMJ26d
Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
The expression of pS6, a downstream adaptor of the PI3Kδ pathway, was anticipated in T and B lymphocytes but this marker was also detected in myeloid cells and plasma cells. This finding suggests that ...
casereports.bmj26d
Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression
Plasma cell mucositis (PCM) is a rare non-neoplastic plasma cell ... dehydrogenase and thus decreasing de novo synthesis of guanosine nucleotides, which B lymphocytes are dependent on. This is the ...
BMJ26d
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
tmu.edu.cn Objectives The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral blood mononuclear cells (PBMCs) at the single-cell level in IgG4-related ...
Nature27d
Interleukins articles from across Nature Portfolio
Interleukins are cytokines produced and secreted mainly by CD3+ and CD4+ T lymphocytes. Interleukins promote development and differentiation of natural killer cells, T and B lymphocytes and ...
Scientific Research Publishing27d
The Role of Human Herpesvirus-Encoded MicroRNA in Host Virus Interaction ()
Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...
gut.bmj28d
Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations
Intraepithelial lymphocytes, mast cells, B lymphocytes and plasma cells were studied by imaging techniques. Differential gene expression and pathway analysis were assessed by microarray and PCR ...
Frontiers1y
Automated EuroFlow approach for standardized in-depth dissection of human circulating B-cells and plasma cells
Background: Multiparameter flow cytometry (FC) immunophenotyping is a key tool for detailed identification and characterization of human blood leucocytes, including B-lymphocytes and plasma cells (PC) ...