B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most common childhood cancer, making up 35% of pediatric cancer cases, but it ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies ...

Last November, results from the MITIGATE trial made headlines at ACR Convergence 2024 with positive phase 3 trial data for inebilizumab, an IgG1 monoclonal antibody targeting CD19, in patients with ...

Germinal centers are machines of rapid evolution. Germinal centers are tiny clusters in the lymph nodes that refine antibodies through proliferation and mutation to create high-affinity B cells that ...

8 The remaining 50% of plasma cells are derived from B cells in the organised lymphoid tissue in the ... We conclude that IgA+ cells in the gut lamina propria are generated in situ from B220+IgM+ ...

WM cells have features of both plasma cells and lymphocytes. Lymphocytes are one of the main types of white blood cells in the immune system. They include T cells and B cells, and they are in many ...

antigens in ELS-associated B cells and plasma cells, respectively. Importantly, a large proportion of ACPA-producing plasma cells surrounding synovial germinal centres were infected with EBV.

Toxic elements, hematology, plasma biochemistry, and protein electrophoresis ... Evolutionary origins of lymphocytes: Ensembles of T-cell and B-cell transcriptional regulators in a cartilaginous fish.

Wojciech Jurczak, MD, PhD, ​​discusses the future of B-cell lymphoma therapy, with a focus on Bruton's tyrosine kinase ...

New study demonstrates how high-affinity B cells "bank" their best traits instead of rolling the dice and risking deleterious mutations, with implications for better vaccine design.

The cells that make up the walls of the finest of all lymphatic vessels have a lobate, oak leaf-like shape that makes them particularly resilient to changes in fluid volume. A similar cell shape also ...

Our blood consists of many cell types that develop through different stages from a precursor type—the blood stem cell. An ...