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Human IgG is a complex molecule composed of four protein chains with attached carbohydrates. A full-size IgG antibody is a Y-shaped ... whereas six bispecific Fab candidate fragments have been ...

Two hinge regions link the Fab and Fc portions of each antibody molecule ... each with unique effector functions. Protein antigens typically elicit IgG1 and IgG3 responses, whereas IgG2 and ...

Immunotherapy. 2012;4(11):1167-1179. Up to half the patients on anti-TNF-α therapies have inadequate responses. Substantial inter- and even intra-individual variations in the pharmacokinetics of ...