By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

Recent advances in molecular antibody biology and structural protein engineering enabled the modification ... including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...

Recombinant antibodies are invented antibodies formed by using recombinant DNA technology. While traditional monoclonal ...

Subsequently, a few human FRs with the highest homology in the Fab sequence database were chosen ... In the self-binding assay, a protein A biosensor captured the antibody to be tested. To ensure ...

Immunotherapy. 2012;4(11):1167-1179. Up to half the patients on anti-TNF-α therapies have inadequate responses. Substantial inter- and even intra-individual variations in the pharmacokinetics of ...

Chronic liver damage in BMP-9-deficient mice or in mice adenovirally overexpressing the selective BMP-9 antagonist activin-like kinase 1-Fc resulted in reduced deposition ... Bone morphogenetic ...

Understanding where and how an antibody binds to its target protein is important for understanding how the ... high affinity and specificity to an antibody antigen binding fragment (Fab), crystal ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

Many vaccines work by introducing a protein to the body that resembles ... It's an exciting step forward in fine-tuning antibody and vaccine-based strategies against HIV and other diseases." ...