New framework leverages 3D protein structures for systems-level analysis of cancer mutations
A study from Cornell researchers could enable a quantum leap forward in identifying and deciphering cancer-driving genetic ...
DNA Microscopy Creates 3D Maps of Life From the Inside Out
What if you could take a picture of every gene inside a living organism—not with light, but with DNA itself? Scientists at ...
The Harvard Crimson4d
HMS Researchers Discover Key Protein in Activating Autoimmune Responses
Donado then compared the structure of Granzyme K to other proteins in the body to hypothesize its function. “I compared the structure, the protein structure Granzyme K, to the structure of all ...
pharmaphorum2d
AlphaFold 3 takes structure predictions well beyond proteins
The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships ... accuracy for the prediction of 3D protein structures, it offers a ...
Nature3d
Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells
Figure 1: Confocal imaging of LLC-PK-1 cells in mitosis. To generate the GFP fusion protein, insert the corresponding cDNA into the multiple cloning site of a pEGFP or other appropriate ...
eLife4d
Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules
This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...
C&EN6d
Protein Carrier Adeno-Associated Virus
To test this approach, we inserted a green fluorescent protein (GFP) nanobody (GFPnb) into the VP1 protein of AAV-DJ inside the capsid and replaced the AAV payload plasmid with a GFP expression ...
C&EN6d
3D Printing for Seafood Mimic: Factors Impacting the Rheology and Texture of Microalgae and Mung Bean Protein Composite ink
Department of Food Science & Technology, National University of Singapore, 2 Science Drive 2, 117542, Singapore ...
greenqueen3d
Alt Protein
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