RNA treatment shows promise for enhancing memory and reducing anxiety
COG-201 uses short hairpin RNA (shRNA) to target and reduce the expression of the serotonin 5-HT2A receptor in the brain.
Nature10y
Cloning of short hairpin RNAs for gene knockdown in mammalian cells
Only coding sequences are targeted, and each shRNA should be chosen such that it contains more than three mismatches to any other gene. Known single-nucleotide polymorphisms should be avoided ...