Beginning in the Original Clone Saga with the creation of Ben Reilly, the Jackal (and Norman Osborn, by extension) made Peter Parker believe that he was a clone, that his memories were false ...
Willem Dafoe made his debut as the villainous Norman Osborn in 2002's Spider-Man, though the Green Goblin's story reached a definitive, comic-accurate end when he was impaled by his glider.