Every second, an adult generates around five million new blood cells to replace aging or dying ones, making the blood system a highly regenerative organ.

differentiation therapy of hematopoietic malignancies, and stem cell expansion for therapeutic benefits. By profiling gene expression in HSCs, we identified an RNA-binding protein called Musashi-2 ...

But if such redirected differentiation occurs at such ... Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system.

Our blood consists of many cell types that develop through different stages from a precursor type -- the blood stem cell. An international research team has now investigated the developmental pathways ...

DLL4 and VCAM1 were used as a supportive environment to drive differentiation to NK cell lineage. Image Credit: ACROBiosystems Figure 6. Hematopoietic cells differentiate to CD3- CD56+ NK Cells ...

The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells. MSK investigators have used ... separated nuclear body that suppresses myeloid leukemic ...

Moreover, the hematopoietic stem cells of anemic mice produced more red blood cells compared to other blood cells, a response ...

Hematopoietic (blood ... and the SMA iPS cells showed reduced capacity to form mature motoneurons in culture when compared with those derived from normal iPS cells. The second case involves ...

Hematopoietic stem cells (HSCs) are immature progenitor cells ... proliferative capacity and to block differentiation. By studying differentiation and self-renewal mechanisms in normal stem cells and ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model ... the intestinal microbiome is required to maintain normal ...