Loki has had a long history in comic books. Created by Stan Lee and ... Trying to manipulate the fate of Asgard, Loki helped Norman Osborn invade Asgard, intent on returning it to the Nine Realms.
Willem Dafoe made his debut as the villainous Norman Osborn in 2002's Spider-Man, though the Green Goblin's story reached a definitive, comic-accurate end when he was impaled by his glider.