In preclinical studies, these agents effectively block the function of MCL-1, reducing the ability of AML cells to survive. However, it has been found that such drugs ... “If one can identify those ...

More information: Rebekka Wegmann et al, Single-cell landscape of innate and acquired drug resistance in acute myeloid ...

Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia ... cells were ...

and cell death. Abnormalities in tyrosine kinases are common in AML, and constitute an attractive therapeutic target. An example is given by the balanced chromosomal translocations (TEL-Abl ...

"Relapse of AML after stem ... only the range of cell types in the bone marrow, but also how those cells were interacting and driving immune responses in the patient. The found that patients ...

Acute myeloid leukemia (AML) is one of the most aggressive and genetically complex cancers, marked by the unchecked growth of immature myeloid cells. Its diversity stems from numerous genetic ...

In preclinical studies, these agents effectively block the function of MCL-1, reducing the ability of AML cells to survive. However, it has been found that ... "If one can identify those escape ...