After working together to defeat Bullseye, Green Goblin comments on Spider-Man's ... following his time in the original Ultimate Universe (Earth-1610) and main Marvel continuity (Earth-616).
Willem Dafoe made his debut as the villainous Norman Osborn in 2002's Spider-Man, though the Green Goblin's story reached a definitive, comic-accurate end when he was impaled by his glider.