Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare genetic disorder that affects the metabolism of γ-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter.

Serotonin is primarily synthesized by neurons in the dorsal Raphe nucleus (DRN) in the midbrain. Serotonin neurons in the DRN project to numerous brain regions, including the arcuate of the ...

More information: Kristine M. Conde et al, Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation, Metabolism (2024). DOI: 10.1016/j.metabol.2024.156099 ...

A metabolic pathway involving GABA that contributes to the production of organic acids, which are important for energy and carbon metabolism in plants. This Nature Research Intelligence Topic ...

Beyond metabolism, other factors can also impact how alcohol affects coordination and drinking behavior. Alcohol suppresses excitatory signals while enhancing gamma-aminobutyric acid (GABA), the main ...

So-called GABA A receptors are proteins that control the flow of ions into and out of cells. As they play such a vital role in how neurons slow down or stop firing, they have become the targets of ...