A lmost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function. Computational protein structure prediction ...

“A key challenge is that subtle structural changes can have profound functional consequences, and thus cell therapies can benefit from improved methods for tuning receptor functions at the ...