For example, activation of a synthetic Notch (synNotch) receptor that binds one antigen can trigger the expression of a CAR targeting another antigen. 5 (4) A CAR controlled remotely via drugs and ...
(Top right) Antigen escape: tumor cells can downregulate or lose the expression of the targeted antigen, resulting in antigen escape, where CAR-T cells are no longer able to recognize and attack tumor ...
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