and Furuichi et al., revealed that certain viral and eukaryotic mRNAs have a cap — a methylated guanosine residue linked to the 5′ end of mRNA through an inverted 5′ to 5′ triphosphate bridge.
The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...
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Circular mRNA produces 200 times more protein, enhancing precision therapy potentialAbe's team overcame this hurdle by introducing a cap structure into the circular mRNA itself. This internal cap structure triggers translation initiation, bypassing the need for IRES sequences ...
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