and Furuichi et al., revealed that certain viral and eukaryotic mRNAs have a cap — a methylated guanosine residue linked to the 5′ end of mRNA through an inverted 5′ to 5′ triphosphate bridge.

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

CleanCap® technology produces optimal 5’Cap structures with over 95% efficiency, creating a co-transcriptional capping solution that improves mRNA yield and process time when compared to legacy ...

Abe's team overcame this hurdle by introducing a cap structure into the circular mRNA itself. This internal cap structure triggers translation initiation, bypassing the need for IRES sequences ...