Independence is a city in and one of two county seats of Jackson County, Missouri, United States. It is a satellite city of Kansas City, Missouri, …Independence is a city in and one of two county seats of Jackson County, Missouri, United States. It is a satellite city of Kansas City, Missouri, and is the largest suburb on the Missouri side of the Kansas City metropolitan area. In 2020, it had a total population of 123,011, making it the fifth-most populous city in Missouri.